Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort.

ABSTRACT:

Background

Inorganic nitrate from the oxidation of endogenously synthesized nitric oxide (NO) or consumed in the diet can be reduced to NO via a complex enterosalivary circulation pathway. The relationship between total nitrate exposure by measured urinary nitrate excretion and blood pressure in a large population sample has not been assessed previously.

Methods

For this cross-sectional study, 24-hour urinary nitrate excretion was measured by spectrophotometry in the 919 participants from the InChianti cohort at baseline and blood pressure measured with a mercury sphygmomanometer.

Results

After adjusting for age and sex only, diastolic blood pressure was 1.9 mm Hg lower in subjects with ≥2 mmol urinary nitrate excretion compared with those excreting <1 mmol nitrate in

SUBMITTER: Smallwood MJ 

PROVIDER: S-EPMC5861588 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature