Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy.

ABSTRACT:

Background

The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to several inflammatory or immune diseases. Here we investigated the expression of the NLRP inflammasome in skeletal muscle and its contribution to DMD.

Results

We find that NLRP3 is expressed in skeletal muscle and show that ApN downregulates NLRP3 via its anti-inflammatory mediator, miR-711. This repression occurs both in vitro in C2C12 myotubes and in vivo after either local (via muscle electrotransfer) or systemic (by using transgenic mice)

SUBMITTER: Boursereau R 

PROVIDER: S-EPMC5861675 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature