Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.

ABSTRACT:

Background

Vascular risk factors, including inflammation, may contribute to dementia development. We investigated the associations between peripheral inflammatory biomarkers and cognitive decline in five domains (memory, construction, language, psychomotor speed, and executive function).

Methods

Community-dwelling older adults from the Ginkgo Evaluation of Memory Study (n = 1,159, aged 75 or older) free of dementia at baseline were included and followed for up to 7 years. Ten biomarkers were measured at baseline representing different sources of inflammation: vascular inflammation (pentraxin 3 and serum amyloid P), endothelial function (endothelin-1), metabolic function (adiponectin, resistin, and plasminogen activating inhibitor-1), oxidative stress (receptor for advanced g

SUBMITTER: Chi GC 

PROVIDER: S-EPMC5861845 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature