Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers.

ABSTRACT: Resveratrol and metformin have been shown to mimic some aspects of caloric restriction and exercise. However, it remains unknown if these molecules also slow age-related synaptic degeneration, as previously shown for caloric restriction and exercise. In this study, we examined the structural integrity of neuromuscular junctions (NMJs) in 2-year-old mice treated with resveratrol and metformin starting at 1 year of age. We found that resveratrol significantly slows aging of NMJs in the extensor digitorum longus muscle of 2-year-old mice. Resveratrol also preserved the morphology of muscle fibers in old mice. Although metformin slowed the rate of muscle fiber aging, it did not significantly affect aging of NMJs. Based on these findings, we sought to determine if resveratrol directly affects N

SUBMITTER: Stockinger J 

PROVIDER: S-EPMC5861854 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature