Ontology highlight
ABSTRACT:
SUBMITTER: Maffei VJ
PROVIDER: S-EPMC5861892 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Maffei Vincent J VJ Kim Sangkyu S Blanchard Eugene E Luo Meng M Jazwinski S Michal SM Taylor Christopher M CM Welsh David A DA
The journals of gerontology. Series A, Biological sciences and medical sciences 20171001 11
The human gastrointestinal microbiota plays a key homeostatic role in normal functioning of physiologic processes commonly undermined by aging. We used a previously validated 34-item frailty index (FI34) to identify changes in gut microbiota community structure associated with biological age of community-dwelling adults. Stool 16S rRNA cDNA libraries from 85 subjects ranging in age (43-79) and FI34 score (0-0.365) were deep sequenced, denoised, and clustered using DADA2. Subject biological age b ...[more]