Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression.

ABSTRACT: Genetically identical organisms grown in homogenous environments differ in quantitative phenotypes. Differences in one such trait, expression of a single biomarker gene, can identify isogenic cells or organisms that later manifest different fates. For example, in isogenic populations of young adult Caenorhabditis elegans, differences in Green Fluorescent Protein (GFP) expressed from the hsp-16.2 promoter predict differences in life span. Thus, it is of interest to determine how interindividual differences in biomarker gene expression arise. Prior reports showed that the thermosensory neurons and insulin signaling systems controlled the magnitude of the heat shock response, including absolute expression of hsp-16.2. Here, we tested whether these regulatory signals might also influence varia

SUBMITTER: Mendenhall A 

PROVIDER: S-EPMC5861906 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature