Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.

ABSTRACT:

Background

We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life.

Methods

We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status,

SUBMITTER: Ard JD 

PROVIDER: S-EPMC5861948 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature