A genetic risk score for fasting plasma glucose is independently associated with arterial stiffness: a Mendelian randomization study.

ABSTRACT: BACKGROUND:Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have been inconsistent between studies and overlap with other clinical conditions is lacking. Our aim was to investigate a potential shared set of risk single nucleotide polymorphisms between relevant cardiometabolic traits and arterial stiffness. METHOD:The study population consisted of 2853 individuals (mean age 72 years, 40% men) from the population-based Malmö Diet and Cancer study, Sweden. Carotid-

SUBMITTER: Gottsater M 

PROVIDER: S-EPMC5861999 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature