Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis.

ABSTRACT:

Objectives

TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide polymorphism position RS3806932. Presently, the phenotypic characteristics in EoE children with the TSLP EoE risk allele are unknown.

Methods

A retrospective analysis was performed of all children with EoE who had TSLP genotyping at The Children's Hospital of Philadelphia from 2008-2014. EoE food allergen triggers, presence of atopic features, IgE mediated food allergy and skin prick testing results were reviewed. The number and type of EoE food allergen triggers were compared with genotype using chi-square analysis. Primary cell cultures from EoE patients with or without the risk allel

SUBMITTER: Fahey LM 

PROVIDER: S-EPMC5862152 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature