Endoscopic score vs. fecal biomarkers for predicting relapse in patients with ulcerative colitis after clinical remission and mucosal healing.

ABSTRACT:

Objectives

Achieving endoscopic remission or decreasing the level of fecal biomarkers as an ideal therapeutic goal in ulcerative colitis has not been determined. This prospective study was to compare the clinical relevance of endoscopic score with fecal biomarkers for predicting relapse after clinical remission and mucosal healing (MH).

Methods

One hundred and sixty-four patients who achieved clinical remission and MH (Mayo endoscopic subscore (MES) 0 or 1) were included. At entry, fecal samples were collected for the measurement of calprotectin, lactoferrin, and hemoglobin. Thereafter patients received masalamine maintenance therapy, and were followed for 12 months.

Results

During the 12-month study, 46 patients (28%) relapsed. The relapse rate was not significantly

SUBMITTER: Yamamoto T 

PROVIDER: S-EPMC5862153 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature