Barrett's esophagus is associated with a distinct oral microbiome.

ABSTRACT:

Objectives

The esophageal microbiome is composed of predominantly oral flora and is altered in reflux-related conditions including Barrett's esophagus (BE). Changes to the esophageal microbiome may be reflected in the oral cavity. Assessing the oral microbiome thus represents a potential non-invasive method to identify patients with BE.

Methods

Patients with and without BE undergoing upper endoscopy were prospectively enrolled. Demographics, clinical data, medications, and dietary intake were assessed. 16S rRNA gene sequencing was performed on saliva samples collected prior to endoscopy. Taxonomic differences between groups were assessed via linear discriminant analysis effect size (LEfSe). Logit models were used to develop microbiome signatures to distinguish BE from non-BE

SUBMITTER: Snider EJ 

PROVIDER: S-EPMC5862155 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature