Protocol for a prospective observational study of adverse drug reactions of anti-epileptic drugs in children in the UK.

ABSTRACT:

Background

Epilepsy is a common chronic disease of children that can be treated with anti-epileptic drugs (AEDs). AEDs, however, have significant side effects. Newer AEDs are thought to have fewer side effects. There have, however, been few comparative studies of AED toxicity. The aim is to compare the safety profile of the most frequently used AEDs by performing a multicentre prospective cohort study. This protocol describes the planned study.

Design

A multicentre prospective cohort study of children on AED treatment in hospitals across the UK. Ethical approval will be obtained.

Sample size

Three thousand children on treatment for epilepsy will be recruited from paediatric clinics. It is expected that this sample size will have the potential to compare toxicity betwe

SUBMITTER: Egunsola O 

PROVIDER: S-EPMC5862226 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature