Non-alcoholic fatty liver disease in 2016.

ABSTRACT:

Introduction

Non-alcoholic fatty liver disease is the commonest cause of liver disease worldwide, and is rapidly becoming the leading indication for liver transplantation.

Sources of data

Original articles, reviews and meta-analyses, guidelines.

Areas of agreement

NAFLD strongly correlates with obesity and insulin resistance; currently, the best management strategy is weight loss and treatment of the metabolic syndrome.

Areas of controversy

Recent data suggest that the presence of fibrosis and not non-alcoholic steatohepatitis (NASH) is the predictor of clinical outcome.

Growing points

Many phase 2 and 3 trials are underway. Drugs hoped to be effective are obeticholic acid, elafibranor, glucagon-like peptide-1 analogues and CCR2/5 inhibitors.

Areas ti

SUBMITTER: Townsend SA 

PROVIDER: S-EPMC5862239 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature