Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model.

ABSTRACT: The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O. felineus is less clear. Here, we present findings that support the inclusion of O. felineus in the Group 1 list of biological carcinogens. Two discrete lines of evidence support the notion that infection with this liver fluke is carcinogenic. First, novel oxysterol-like metabolites

SUBMITTER: Gouveia MJ 

PROVIDER: S-EPMC5862325 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature