Development of an in vivo bone fatigue damage model using axial compression of the rabbit forelimb.

ABSTRACT: Many nontraumatic fractures seen clinically in patients with metabolic bone disorders or on antiresorptive treatment show an increased incidence of microdamage accumulation and impaired intracortical remodeling. However, the lack of basal remodeling and Haversian bone in rodents limits their translatability in studying bone damage repair mechanisms. The work presented here demonstrates the development of the forelimb loading model in rabbits, the smallest mammal with intracortical Haversian remodeling. The forelimbs of post-mortem female New Zealand white rabbits were loaded in axial end compression to determine their basic monotonic and fatigue properties. Following time zero characterization, stress fractures were created in vivo and animals were allowed to recover for a period of two to

SUBMITTER: Buettmann EG 

PROVIDER: S-EPMC5862430 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature