Artificial selection increased body weight but induced increase of runs of homozygosity in Hanwoo cattle.

ABSTRACT: Artificial selection has been demonstrated to have a rapid and significant effect on the phenotype and genome of an organism. However, most previous studies on artificial selection have focused solely on genomic sequences modified by artificial selection or genomic sequences associated with a specific trait. In this study, we generated whole genome sequencing data of 126 cattle under artificial selection, and 24,973,862 single nucleotide variants to investigate the relationship among artificial selection, genomic sequences and trait. Using runs of homozygosity detected by the variants, we showed increase of inbreeding for decades, and at the same time demonstrated a little influence of recent inbreeding on body weight. Also, we could identify ~0.2 Mb runs of homozygosity segment which may

SUBMITTER: Kim K 

PROVIDER: S-EPMC5862439 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature