Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa.

ABSTRACT:

Background

Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activities beyond the recommended transmission assessment survey (TAS).

Methodology

TAS was first conducted in American Samoa in 2011 (TAS 1) and a repeat TAS was carried out in 2015 (TAS 2). Circulating filarial antigen (CFA) and serologic results from both surveys were analyzed to determine whether interruption of LF transmission has been achieved in American Samoa.

Principal findings

A total of 1,134 and 864 children (5-10 years old) were enrolled in TAS 1 a

SUBMITTER: Won KY 

PROVIDER: S-EPMC5862496 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature