The importance of geometry in the corneal micropocket angiogenesis assay.

ABSTRACT: The corneal micropocket angiogenesis assay is an experimental protocol for studying vessel network formation, or neovascularization, in vivo. The assay is attractive due to the ease with which the developing vessel network can be observed in the same animal over time. Measurements from the assay have been used in combination with mathematical modeling to gain insights into the mechanisms of angiogenesis. While previous modeling studies have adopted planar domains to represent the assay, the hemispherical shape of the cornea and asymmetric positioning of the angiogenic source can be seen to affect vascular patterning in experimental images. As such, we aim to better understand: i) how the geometry of the assay influences vessel network formation and ii) how to relate observations from plana

SUBMITTER: Grogan JA 

PROVIDER: S-EPMC5862519 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature