The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome.

ABSTRACT: The SRC Kinase Adaptor Phosphoprotein 2 (SKAP2) is a broadly expressed adaptor associated with the control of actin-polymerization, cell migration, and oncogenesis. After activation of different receptors at the cell surface, this dimeric protein serves as a platform for assembling other adaptors such as FYB and some SRC family kinase members, although these mechanisms are still poorly understood. The goal of this study is to map the SKAP2 interactome and characterize which domains or binding motifs are involved in these interactions. This is a prerequisite to finely analyze how these pathways are integrated in the cell machinery and to study their role in cancer and other human diseases when this network of interactions is perturbed. In this work, the domain and the binding motif of fourt

SUBMITTER: Bureau JF 

PROVIDER: S-EPMC5862564 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature