Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants.

ABSTRACT: Non-syndromic orofacial clefts (NSOFC), which include cleft lip and palate (CLP), cleft lip only (CLO), and cleft palate only (CPO), contains a range of disorders affecting the lips and oral cavity. No systematic review and meta-analysis has been carried out to synthesize the prevalence of NSOFC in Chinese perinatal infants. We aimed to quantify and understand the variation of prevalence national and regional levels. Four English databases and four Chinese databases were searched using a comprehensive search strategy from inception to April 2017. The random effect model was used for this meta-analysis. To determine the sources of heterogeneity, subgroup analyses and meta-regression were conducted based on different categories. The protocol has been pre-registered in the PROSPERO, number CR

SUBMITTER: Fan D 

PROVIDER: S-EPMC5862631 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature