Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.

ABSTRACT: Essentials Genetic variants controlling gene regulation have not been explored in pharmacogenomics. We tested liver expression quantitative trait loci for association with warfarin dose response. A novel predictor for increased warfarin dose response in African Americans was identified. Precision medicine must take into account population-specific variation in gene regulation.

Summary

Background Warfarin is commonly used to control and prevent thromboembolic disorders. However, because of warfarin's complex dose-requirement relationship, safe and effective use is challenging. Pharmacogenomics-guided warfarin dosing algorithms that include the well-established VKORC1 and CYP2C9 polymorphisms explain only a small proportion of inter-individual variability in African Americans (AAs). O

SUBMITTER: Hernandez W 

PROVIDER: S-EPMC5862636 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature