Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.

ABSTRACT:

Background

Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics.

Purpose

Develop practical guidelines for single dose external beam preoperative APBI.

Methods

Recommended dose constraints were derived from pooled dosimetry estimates from 2 clinical trials. In an American dose escalation trial, a uniform 15, 18 or 21 Gy dose has previously been evaluated for non-lobular cT1N0 or low

SUBMITTER: Charaghvandi RK 

PROVIDER: S-EPMC5862640 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature