The predictive value of nadir neutrophil count during treatment of cervical cancer: Interactions with tumor hypoxia and interstitial fluid pressure (IFP).

ABSTRACT:

Background and purpose

Hypoxia, high interstitial fluid pressure (IFP) and immune effects have individually been shown to modulate radiotherapy (RT) response in cervical cancer. The aim of this study was to investigate the interplay between hypoxia or IFP and circulating neutrophil levels, and their combined effect on survival following RT.

Material and methods

A total of 287 FIGO stage IB to IIIB cervical cancer patients treated with RT or RT and cisplatin (RTCT) were included. Tumor hypoxia and IFP were measured at baseline prior to treatment. Absolute neutrophil count (ANC) was measured at baseline and weekly during treatment. Median follow up was 7.1 years.

Results

High nadir ANC at the point of maximal myelosuppression was a stronger predictor of inferior surviva

SUBMITTER: Glicksman R 

PROVIDER: S-EPMC5862663 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature