Retrospective assessment of MRI-based volumetric changes of normal tissues in glioma patients following radio(chemo)therapy.

ABSTRACT: In glioma patients, linac-based photon beam irradiation is a widely applied therapy, which achieves highly conformal target volume coverage, but is also known to cause side-effects to adjacent areas of healthy tissue. Apart from subjective measures, such as quality of life assessment and neurocognitive function tests, objective methods to quantify tissue damage are needed to assess this impact. Magnetic resonance imaging (MRI) is a well-established method for brain tumor diagnoses as well as assessing treatment response. In this study, we retrospectively assessed volumetric changes of gray matter (GM) and white matter (WM) in glioma patients following photon irradiation using a heterogeneous MRI-dataset obtained in routine clinical practice at different sites with imaging parameters and ma

SUBMITTER: Gommlich A 

PROVIDER: S-EPMC5862681 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature