Durability of antiretroviral therapy regimens and determinants for change in HIV-1-infected patients in the TREAT Asia HIV Observational Database (TAHOD-LITE).

ABSTRACT:

Background

The durability of first-line regimen is important to achieve long-term treatment success for the management of HIV infection. Our analysis describes the duration of sequential ART regimens and identifies the determinants leading to treatment change in HIV-positive patients initiating in Asia.

Methods

All HIV-positive adult patients initiating first-line ART in 2003-2013, from eight clinical sites among seven countries in Asia. Patient follow-up was to May 2014. Kaplan-Meier curves were used to estimate the time to second-line ART and third-line ART regimen. Factors associated with treatment durability were assessed using Cox proportional hazards model.

Results

A total of 16,962 patients initiated first-line ART. Of these, 4,336 patients initiated second-lin

SUBMITTER: Martinez-Vega R 

PROVIDER: S-EPMC5862772 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature