Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time.

ABSTRACT: Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patients with MS walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects walked at all the different patient's paces, allowing for comparisons independent of walking velocity. Kinematic analysis revealed pronounced restrictions in knee and ankle joint excursion, increased gait variability and asymmetry along with impaired dynamic stability in patients. The most discriminative single gait parameter, differentiating patients from controls with an accuracy of 83.3% (χ² test; p = 0.0001), was reduced knee range of

SUBMITTER: Filli L 

PROVIDER: S-EPMC5862880 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature