Real-world effectiveness of osteoporosis therapies for fracture reduction in post-menopausal women.

ABSTRACT: Studies examining real-world effectiveness of osteoporosis therapies are beset by limitations due to confounding by indication. By evaluating longitudinal changes in fracture incidence, we demonstrated that osteoporosis therapies are effective in reducing fracture risk in real-world practice settings.

Introduction

Osteoporosis therapies have been shown to reduce incidence of vertebral and non-vertebral fractures in placebo-controlled randomized clinical trials. However, information on the real-world effectiveness of these therapies is limited.

Methods

We examined fracture risk reduction in older, post-menopausal women treated with osteoporosis therapies. Using Medicare claims, we identified 1,278,296 women age ≥ 65 years treated with zoledronic acid, oral bisphosphonates, den

SUBMITTER: Yusuf AA 

PROVIDER: S-EPMC5862911 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature