[¹⁸F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice.

ABSTRACT:

Purpose

The association of Zika virus (ZIKV) infection and development of neurological sequelae require a better understanding of the pathogenic mechanisms causing severe disease. The purpose of this study was to evaluate the ability and sensitivity of positron emission tomography (PET) imaging using [¹⁸F]DPA-714, a translocator protein (TSPO) 18 kDa radioligand, to detect and quantify neuroinflammation in ZIKV-infected mice.

Procedures

We assessed ZIKV-induced pathogenesis in wild-type C57BL/6 mice administered an antibody to inhibit type I interferon (IFN) signaling. [¹⁸F]DPA-714 PET imaging was performed on days 3, 6, and 10 post-infection (PI), and tissues were subsequently processed for histological evaluation, quantification of microgliosis, and d

SUBMITTER: Kuszpit K 

PROVIDER: S-EPMC5862915 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature