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Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source.

ABSTRACT: We demonstrate that phase retrieval and tomographic imaging at the organ level of small animals can be advantageously carried out using the monochromatic radiation emitted by a compact x-ray light source, without further optical elements apart from source and detector. This approach allows to carry out microtomography experiments which - due to the large performance gap with respect to conventional laboratory instruments - so far were usually limited to synchrotron sources. We demonstrate the potential by mapping the functional soft tissue within the guinea pig and marmoset cochlea, including in the latter case an electrical cochlear implant. We show how 3d microanatomical studies without dissection or microscopic imaging can enhance future research on cochlear implants.

SUBMITTER: Topperwien M

PROVIDER: S-EPMC5862924 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source.

Töpperwien Mareike M Gradl Regine R Keppeler Daniel D Vassholz Malte M Meyer Alexander A Hessler Roland R Achterhold Klaus K Gleich Bernhard B Dierolf Martin M Pfeiffer Franz F Moser Tobias T Salditt Tim T

Scientific reports 20180321 1

We demonstrate that phase retrieval and tomographic imaging at the organ level of small animals can be advantageously carried out using the monochromatic radiation emitted by a compact x-ray light source, without further optical elements apart from source and detector. This approach allows to carry out microtomography experiments which - due to the large performance gap with respect to conventional laboratory instruments - so far were usually limited to synchrotron sources. We demonstrate the po ...[more]

PMID: 29563553

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