Comparative analysis of human Wharton's jelly mesenchymal stem cells derived from different parts of the same umbilical cord.

ABSTRACT: Easy isolation, lack of ethical issues, high proliferation, multi-lineage differentiation potential and immunomodulatory properties of umbilical cord (UC)-derived mesenchymal stem cells (MSCs) make them a valuable tool in stem cell research. Recently, Wharton's jelly (WJ) was proven as the best MSC source among various compartments of UC. However, it is still unclear whether or not Wharton's jelly-derived MSCs (WJMSCs) from different parts of the whole cord exhibit the same characteristics. There may be varied MSCs present in different parts of WJ throughout the length of the UC. For this purpose, using an explant attachment method, WJMSCs were isolated from three different parts of the UC, mainly present towards the placenta (mother part), the center of the whole cord (central part) and t

SUBMITTER: Bharti D 

PROVIDER: S-EPMC5862947 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature