Risk factors and methylenetetrahydrofolate reductase gene in congenital heart disease.

ABSTRACT:

Background

Congenital heart disease (CHD), which involve congenital cardiovascular malformations that occur during an embryo stage, may be the result of a complex interaction between genetic factors and environmental factors. The homozygous 677 T/T MTHFR gene and potential factors have been associated with CHD. Our objective was to study associations between potential environmental risk factors and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in CHD.

Methods

A total of 346 children with CHD and 237 healthy children were recruited. Their parents were also enlisted in the study and interviewed face-to-face to identify potential environmental risk factors. The MTHFR genotype was analyzed by restriction fragment length polymorphism (RFLP). Interactions between

SUBMITTER: Wang L 

PROVIDER: S-EPMC5863123 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature