Bronchoalveolar lavage fluid microbiota dysbiosis in infants with protracted bacterial bronchitis.

ABSTRACT:

Background

Protracted bacterial bronchitis (PBB) is a chronic purulent bronchitis which could cause recurrent coughing and wheezing in infants. Based on previous reports, main pathogens which caused PBB were identified in the patients, but their impacts on lung microbiota dysbiosis remain unclear.

Methods

In this study, bronchoalveolar lavage fluid (BALF) was collected from PBB infants and tracheomalacia (TM) infants younger than 3 years old under the instruction of Shenzhen Children's Hospital, and 12 samples were randomly selected for 16S rDNA analysis in each group. Based on the results of bacterial composition, the microbiota diversity and co-occurrence network in PBB and TM group were detected and compared.

Results

Microbiota diversity was significantly lower in

SUBMITTER: Bao Y 

PROVIDER: S-EPMC5863146 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature