Advanced lesion symptom mapping analyses and implementation as BCBtoolkit.

ABSTRACT:

Background

Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the associations between executive, semantic, and language production functions.

Findings

Here, we provide, for the first time, a set of complementary solutions for measuring the impact of a given lesion on the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesions, revealed a large set of directly and indirectly disconnected brain regions that h

SUBMITTER: Foulon C 

PROVIDER: S-EPMC5863218 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature