A pooled analysis of mesenchymal stem cell-based therapy for liver disease.

ABSTRACT: BACKGROUND:Liver disease is a major cause of death and disability. Mesenchymal stem cells (MSCs) show promise for the treatment of liver disease. However, whether MSC-based therapy is more effective than conventional treatment is unclear, as are the optimal MSC source, the administration frequency, and the most effective MSC delivery route. We therefore undertook a systematic review and meta-analysis of the therapeutic efficacy of MSCs against liver disease and the related factors. METHODS:We systematically searched Medline (PubMed), Cochrane Library, EMBASE, ClinicalTrials.gov, and SinoMed CBM to identify studies published up to June 2017 involving liver disease patients receiving MSC-based therapy and which reported estimates of liver function during the follow-up period. RESULTS:Thirty-

SUBMITTER: Zhao L 

PROVIDER: S-EPMC5863358 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature