Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice.

ABSTRACT:

Background

Calorie restriction (CR), which has a potent anti-inflammaging effect, has been demonstrated to induce dramatic changes in the gut microbiota. Whether the modulated gut microbiota contributes to the attenuation of inflammation during CR is unknown, as are the members of the microbial community that may be key mediators of this process.

Results

Here, we report that a unique Lactobacillus-predominated microbial community was rapidly attained in mice within 2 weeks of CR, which decreased the levels of circulating microbial antigens and systemic inflammatory markers such as tumour necrosis factor alpha (TNF-α). Lactobacillus murinus CR147, an isolate in the most abundant operational taxonomic unit (OTU) enriched by CR, downregulated interleukin-8 production in TNF-α-s

SUBMITTER: Pan F 

PROVIDER: S-EPMC5863386 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature