Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier.

ABSTRACT:

Background

Gut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three recognised mechanisms exist by which the microbiome influences the gut-brain axis: modification of autonomic/sensorimotor connections, immune activation, and neuroendocrine pathway regulation. We hypothesised interactions between circulating gut-derived microbial metabolites, and the blood-brain barrier (BBB) also contribute to the gut-brain axis. Propionate, produced from dietary substrates by colonic bacteria, stimulates intestinal gluconeogenesis and is associated with reduced stress behaviours, but its potential endocrine role has not been addressed.

Results

After demonstrating expression of the propion

SUBMITTER: Hoyles L 

PROVIDER: S-EPMC5863458 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature