Functionalized rare earth-doped nanoparticles for breast cancer nanodiagnostic using fluorescence and CT imaging.

ABSTRACT:

Background

Breast cancer is the second leading cause of cancer death among women and represents 14% of death in women around the world. The standard diagnosis method for breast tumor is mammography, which is often related with false-negative results leading to therapeutic delays and contributing indirectly to the development of metastasis. Therefore, the development of new tools that can detect breast cancer is an urgent need to reduce mortality in women. Here, we have developed Gd₂O₃:Eu³⁺ nanoparticles functionalized with folic acid (FA), for breast cancer detection.

Results

Gd₂O₃:Eu³⁺ nanoparticles were synthesized by sucrose assisted combustion synthesis and functionalized with FA using EDC-NHS coupling. Th

SUBMITTER: Jain A 

PROVIDER: S-EPMC5863469 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature