Solution NMR of SNAREs, complexin and α-synuclein in association with membrane-mimetics.

ABSTRACT: SNARE-mediated membrane fusion is a ubiquitous process responsible for intracellular vesicle trafficking, including membrane fusion in exocytosis that leads to hormone and neurotransmitter release. The proteins that facilitate this process are highly dynamic and adopt multiple conformations when they interact with other proteins and lipids as they form highly regulated molecular machines that operate on membranes. Solution NMR is an ideal method to capture high-resolution glimpses of the molecular transformations that take place when these proteins come together and work on membranes. Since solution NMR has limitations on the size of proteins and complexes that can be studied, lipid bilayer model membranes cannot be used in these approaches, so the relevant interactions are typically studi

SUBMITTER: Liang B 

PROVIDER: S-EPMC5863748 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature