Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep.

ABSTRACT: How are brief encounters transformed into lasting memories? Previous research has established the role of non-rapid eye movement (NREM) sleep, along with its electrophysiological signatures of slow oscillations (SOs) and spindles, for memory consolidation [1-4]. In related work, experimental manipulations have demonstrated that NREM sleep provides a window of opportunity to selectively strengthen particular memory traces via the delivery of auditory cues [5-10], a procedure known as targeted memory reactivation (TMR). It has remained unclear, however, whether TMR triggers the brain's endogenous consolidation mechanisms (linked to SOs and/or spindles) and whether those mechanisms in turn mediate effective processing of mnemonic information. We devised a novel paradigm in which associative m

SUBMITTER: Cairney SA 

PROVIDER: S-EPMC5863764 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature