Altered ENaC is Associated With Aortic Baroreceptor Dysfunction in Chronic Heart Failure.

ABSTRACT:

Background

Abnormal baroreceptor function contributes to attenuated arterial baroreflex sensitivity in chronic heart failure (CHF). As a mechanosensor in mammalian nonepithelium, the epithelial sodium channel (ENaC) is an amiloride-sensitive and voltage-independent ion channel. The ENaC is thought to be a component of baroreceptor mechanosensitive ion channels in aortic baroreceptor cell bodies and nerve terminals. In this study, therefore, we measured the expression and activation of the ENaC in nodose neuronal cell bodies and aortic baroreceptor nerve terminals in sham and CHF rats.

Methods and results

CHF was induced by surgical ligation of left coronary artery. The development of CHF was confirmed by hemodynamic and morphological characteristics. The aortic baroreceptor

SUBMITTER: Li YL 

PROVIDER: S-EPMC5863778 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature