Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls.

ABSTRACT:

Background

Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely known as a mechanism of fetal growth. However, it is unclear whether and how DNA methylation of FGFR2 gene in the placenta is associated with full-term low birth weight. This case-control study aims to explore the links between FGFR2 methylation in placenta and full-term low birth weight and to further examine the mediation effect of placental surface area on this association.

Results

We conducted analyses for each of the five valid CpG sites at FGFR2 in 165

SUBMITTER: Tian FY 

PROVIDER: S-EPMC5863829 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature