Integrative genomics identifies new genes associated with severe COPD and emphysema.

ABSTRACT:

Background

Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability and in most cases, fail to implicate specific genes. Integrative methods that combine gene expression data with GWAS can provide more power in discovering disease-associated genes and give mechanistic insight into regulated genes.

Methods

We applied a recently described method that imputes gene expression using reference transcriptome data to genome-wide association studies for two phenotypes (severe COPD and quantitative emphysema) and blood and lung tissue gene expression datasets. We further tested the potential causality of individual genes using multi-v

SUBMITTER: Sakornsakolpat P 

PROVIDER: S-EPMC5863845 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature