The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.

ABSTRACT:

Background

Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram timing, and change with treatment. Multivariable prediction models for CBC risk are needed and MD could contribute to these.

Methods

We conducted a case-control study of MD and CBC risk in phase II of the WECARE study where cases had a CBC diagnosed ≥ 2 years after first diagnosis at age <55 years and controls had unilateral breast cancer (UBC) with similar follow-up time. We retrieved film mammograms of the unaffected breast from two time points, prior to/at the time of the first diagnosis (253 CBC cases, 269 UBC controls) and ≥ 6 months up to 48 months foll

SUBMITTER: Knight JA 

PROVIDER: S-EPMC5863854 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature