Germline breast cancer susceptibility gene mutations and breast cancer outcomes.

ABSTRACT:

Background

It is unclear whether germline breast cancer susceptibility gene mutations affect breast cancer related outcomes. We wanted to evaluate mutation patterns in 20 breast cancer susceptibility genes and correlate the mutations with clinical characteristics to determine the effects of these germline mutations on breast cancer prognosis.

Methods

The study cohort included 480 ethnic Chinese individuals in Taiwan with at least one of the six clinical risk factors for hereditary breast cancer: family history of breast or ovarian cancer, young age of onset for breast cancer, bilateral breast cancer, triple negative breast cancer, both breast and ovarian cancer, and male breast cancer. PCR-enriched amplicon-sequencing on a next generation sequencing platform was used to dete

SUBMITTER: Wang YA 

PROVIDER: S-EPMC5863855 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature