A Comparative Assessment of Implant Site Viability in Humans and Rats.

ABSTRACT: Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an osteopenic phenotype, reminiscent of the bone health that has been reported for the average dental implant patient population. Second, osteotomies were produced in healed tooth extraction sites and therefore represented the placement of most implants in patients. Commercially available drills were then used to produce osteotomies in a patient cohort and in the rat model. Molecular, cellular, and histologic analyses demonstrated a close alignment between the responses of human an

SUBMITTER: Chen CH 

PROVIDER: S-EPMC5863872 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature