Second-generation p-values: Improved rigor, reproducibility, & transparency in statistical analyses.

ABSTRACT: Verifying that a statistically significant result is scientifically meaningful is not only good scientific practice, it is a natural way to control the Type I error rate. Here we introduce a novel extension of the p-value-a second-generation p-value (pδ)-that formally accounts for scientific relevance and leverages this natural Type I Error control. The approach relies on a pre-specified interval null hypothesis that represents the collection of effect sizes that are scientifically uninteresting or are practically null. The second-generation p-value is the proportion of data-supported hypotheses that are also null hypotheses. As such, second-generation p-values indicate when the data are compatible with null hypotheses (pδ = 1), or with alternative hypotheses (pδ = 0), or when the data are

SUBMITTER: Blume JD 

PROVIDER: S-EPMC5863943 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature