Facilitated recruitment of mesenchymal stromal cells by bone marrow concentrate and platelet rich plasma.

ABSTRACT:

Background

Biologics containing growth factors are frequently used to enhance healing after musculoskeletal injuries. One mechanism of action is thought to be though the ability of biologics to induce homing and migration of endogenous mesenchymal stromal cells (MSCs) to a target tissue. However, the ability of biologics to stimulate chemotaxis (directed migration of cells) and chemokinesis (increase rate of cell migration) of MSCs is unknown.

Hypothesis/purpose

The aim of this study was to directly compare the ability of biologics including platelet rich plasma (PRP) and bone marrow concentrate (BMC) to induce MSC migration. The hypothesis was that leukocyte-low platelet rich plasma (Llo PRP) would induce migration to a greater extent than leukocyte-high platelet rich plasm

SUBMITTER: Holmes HL 

PROVIDER: S-EPMC5864018 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature