The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

ABSTRACT: The ecology of antibiotic resistance involves the interplay of a long natural history of antibiotic production in the environment, and the modern selection of resistance in pathogens through human use of these drugs. Important components of the resistome are intrinsic resistance genes of environmental bacteria, evolved and acquired over millennia, and their mobilization, which drives dissemination in pathogens. Understanding the dynamics and evolution of resistance across bacterial taxa is essential to address the current crisis in drug-resistant infections. Here we report the exploration of antibiotic resistance in the Paenibacillaceae prompted by our discovery of an ancient intrinsic resistome in Paenibacillus sp. LC231, recovered from the isolated Lechuguilla cave environment. Using bio

SUBMITTER: Pawlowski AC 

PROVIDER: S-EPMC5864230 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature