Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood.

ABSTRACT:

Objectives

To study the effects of repeated, infancy-onset dietary counseling on a detailed metabolic profile. Effects of dietary saturated fat replacement on circulating concentrations of metabolic biomarkers still remain unknown.

Study design

The Special Turku Coronary Risk Factor Intervention Project (STRIP) study is a longitudinal, randomized atherosclerosis prevention trial in which repeated dietary counseling aimed at reducing the proportion of saturated fat intake. Nuclear magnetic resonance metabolomics quantified circulating metabolites from serum samples assessed at age 9 (n = 554), 11 (n = 553), 13 (n = 508), 15 (n = 517), 17 (n = 457), and 19 (n = 417) years.

Results

The intervention reduced dietary intake of saturated fat (mean difference in daily percent

SUBMITTER: Lehtovirta M 

PROVIDER: S-EPMC5864506 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature