Association of Interleukin-1 Gene cluster polymorphisms with coronary slow flow phenomenon.

ABSTRACT:

Objective

Coronary slow flow phenomenon (CSFP) is characterized by the decreased rate of contrast progression in epicardial coronary arteries in the absence of significant coronary stenosis. Mounting evidence has showed a significant association between inflammation and CSFP severity. This study aimed to evaluate possible associations between interleukin-1 receptor antagonist (IL-1ra) gene variable number tandem repeat (VNTR), IL-1ß -511 single nucleotide (SNP), and IL-1ß+3954 SNP mutations with CSFP.

Methods

Forty-eight patients with CSFP and 62 controls with angiographically normal coronary arteries were prospectively enrolled in the study. Genotypes were assessed using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism (PCR-RFLP) technique.

SUBMITTER: Mutluer FO 

PROVIDER: S-EPMC5864788 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature